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MDPI-PublisherofOpenAccessJournals(function(i,s,o,g,r,a,m){i['GoogleAnalyticsObject']=r;i[r]=i[r]||function(){(i[r].q=i[r].q||[]).push(arguments)},i[r].l=1*newDate();a=s.createElement(o),m=s.getElementsByTName(o)[0];a.async=1;a.src=g;m.parentNode.insertBefore(a,m)})(window,document,'script','/analytics.js','ga');ga('create','UA--2','auto');ga('require','displayfeatures');ga('send','peview');(function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':newDate().getTime(),event:'gtm.js'});varf=d.getElementsByTName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-WPK7SW5');_linkedin_partner_id="";window._linkedin_data_partner_ids=window._linkedin_data_partner_ids||[];window._linkedin_data_partner_ids.push(_linkedin_partner_id);(function(){vars=document.getElementsByTName("script")[0];varb=document.createElement("script");b.type="text/jascript";b.async=true;b.src="snap.licdn.com/li.lms-analytics/insight.min.js";s.parentNode.insertBefore(b,s);})();JournalsTopicsInformationForAuthorsForReviewersForEditorsForLibrariansForPublishersForSocietiesForConferenceOrganizersOpenAccessPolicyInstitutionalOpenAccessProgramSpecialIssuesGuidelinesEditorialProcessResearchandPublicationEthicsArticleProcessingChargesAwardsAuthorServicesInitiativesSciforumMDPIBooksPreprintsScilitSciProfilesEncyclopediaJAMSProceedingsSeriesAboutOverviewContactCareersSignIn/SignUpNoticeYoucanmakesubmissionstootherjournalshere.clearNoticeYouareaccessingamachine-readablepe.Inordertobehuman-readable,pleaseinstallanRSSreader.ContinueCancelclearAllarticlespublishedbyMDPIaremadeimmediatelyailableworldwideunderanopenaccesslicense.NospecialpermissionisrequiredtoreuseallorpartofthearticlepublishedbyMDPI,includingfiguresandtables.ForarticlespublishedunderanopenaccessCreativeCommonCCBYlicense,anypartofthearticlemaybereusedwithoutpermissionprovidedthattheoriginalarticleisclearlycited.FeaturePapersrepresentthemostadvancedresearchwithsignificantpotentialforhighimpactinthefield.FeaturePapersaresubmitteduponindividualinvitationorrecommendationbythescientificeditorsandundergopeerreviewpriortopublication.TheFeaturePapercanbeeitheranoriginalresearcharticle,asubstantialnovelresearchstudythatofteninvolvesseveraltechniquesorapproaches,oracomprehensivereviewpaperwithconciseandpreciseupdatesonthelatestprogressinthefieldthatsystematicallyreviewsthemostexcitingadvancesinscientificliterature.Thistypeofpaperprovidesanoutlookonfuturedirectionsofresearchorpossibleapplications.Editor’sChoicearticlesarebasedonrecommendationsbythescientificeditorsofMDPIjournalsfromaroundtheworld.Editorsselectasmallnumberofarticlesrecentlypublishedinthejournalthattheybelievewillbeparticularlyinterestingtoauthors,orimportantinthisfield.Theaimistoprovideasnapshotofsomeofthemostexcitingworkpublishedinthevariousresearchareasofthejournal.Youseemtohejascriptdisabled.Pleasenotethatmanyofthepefunctionalitieswon'tworkasexpectedwithoutjascriptenabled.clearsearchmenuJournalsTopicsInformationForAuthorsForReviewersForEditorsForLibrariansForPublishersForSocietiesForConferenceOrganizersOpenAccessPolicyInstitutionalOpenAccessProgramSpecialIssuesGuidelinesEditorialProcessResearchandPublicationEthicsArticleProcessingChargesAwardsAuthorServicesInitiativesSciforumMDPIBooksPreprintsScilitSciProfilesEncyclopediaJAMSProceedingsSeriesAboutOverviewContactCareersSignIn/SignUpSubmitAdvancingOpenScienceformorethan25yearsMDPIisapioneerinscholarlyopenaccesspublishingandhassupportedacademiccommunitiessince1996. SearchforArticles:Title/KeywordAuthor/AffiliationJournalAllJournalsAcousticsActuatorsAdministrativeSciencesAdolescentsAdvancesinRespiratoryMedicineAerospacericultureriEngineeringrochemicalsronomyAIAlgorithmsAllergiesAlloysAnalyticaAnalyticsAnatomiaAnimalsAntibioticsAntibodiesAntioxidantsAppliedBiosciencesAppliedMechanicsAppliedMicrobiologyAppliedNanoAppliedSciencesAppliedSystemInnovation(ASI)AppliedChemAppliedMathAquacultureJournalArchitectureArthropodaArtsAstronomyAtmosphereAtomsAudiologyResearchAutomationAxiomsBacteriaBatteriesBehioralSciencesBeveresBigDataandCognitiveComputing(BDCC)BioChemBioengineeringBiologicsBiologyBiologyandLifeSciencesForumBiomassBiomechanicsBioMedBiomedicinesBioMedInformaticsBiomimeticsBiomoleculesBiophysicaBiosensorsBioTechBirdsBrainSciencesBuildingsBusinessesCCancersCardiogeneticsCatalystsCellsCeramicsChallengesChemEngineeringChemistryChemistryProceedingsChemosensorsChildrenChipsCivilEngCleanTechnologies(CleanTechnol.)ClimateClinicalandTranslationalNeuroscience(CTN)ClinicsandPracticeClocks&SleepCoastsCoatingsColloidsandInterfacesColorantsCommoditiesCompoundsComputationComputerSciences&MathematicsForumComputersCondensedMatterConservationConstructionMaterialsCorrosionandMaterialsDegradation(CMD)CosmeticsCOVIDCropsCryptographyCrystalsCurrentIssuesinMolecularBiology(CIMB)CurrentOncologyDairyDataDentistryJournalDermatoDermatopathologyDesignsDiabetologyDinosticsDieteticsDigitalDisabilit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nducedObesityviaRegulatingLipoproteinLipaseActivityTechnologiesAnaPrioriDiscussionoftheFillFrontStabilityinSemisolidCastingBiologyCommunityCompositionoftheLunaNegraHypersalineMicrobialMat,ArgentineanAndesCellsHowtoSlowdowntheTickingClockSymmetryStructuralBrainAsymmetriesforLangueacrossPrimatesRecentArticles attachmentSupplementarymaterial:SupplementaryFile1(ZIP,156KiB)get_appsubjectViewonlineas:AbstractPeFull-TextHTMLOpenAccessArticleMulti-RiskAssessmenttoEvaluatetheEnvironmentalImpactofOutdoorPigProductionAreas:ACaseStudybyCarmoHorta,NatáliaRoque,MartaBatistaandAntónioCanatárioDuarteronomy2022,12(8),1898;doi.org/10.3390/ronomy(registering DOI)-12Aug2022AbstractOutdoorpigproduction(OPP)canbeconsideredanintensivesysteminmanyareasoftheMediterraneanregion.Theconcentrationoftherainfallinthewinterseason,theOPPx2019;stopographicandsoilproperties,togetherwiththecontinuousinputoffoodandpigsx2019;excreta,contribute[...]Readmore.Outdoorpigproduction(OPP)canbeconsideredanintensivesysteminmanyareasoftheMediterraneanregion.Theconcentrationoftherainfallinthewinterseason,theOPP’stopographicandsoilproperties,togetherwiththecontinuousinputoffoodandpigs’excreta,contributetoaprofoundincreaseinthenutrientsleachingandsoilerosion.ThisworkaimedtoevaluatetheaccuracyoftheDRASTIC-LUindexandtheRevisedUniversalSoilLossEquation(RUSLE)toprovideearlyinformationtoimprovetheplanningofthistypeofpigproductionthroughmoreadequatelocationandsustainablemanementpractices.ThetwomodelswereappliedtoanOPPwith2.24ha,withaheyanimalcharge(oneadultper1.120m2).Theresultsshowedthat85%oftheOPPareahasamoderaterisktothevulnerabilityindextogroundwaterpollutionand15%highrisk.Theriskofsoilerosionrangedfromveryseveretoextremelyseverein96%ofthearea.TheDRASTIC-LUindexesandtheRUSLEmodelproduceamulti-riskassessmentthatreedwiththeobservedfielddata.ThesetwomodelsshowedaccuracytobeusedforearlyassessmentwhenchoosingthebestlocationandimprovingmanementpracticesforOPPsystems.Fullarticle(ThisarticlebelongstotheSpecialIssueSoilSustainabilityintheAnthropocene)9658;9660;ShowFiguresFigure1Figure2---Figure3---Figure4---Figure5get_appsubjectViewonlineas:AbstractPeFull-TextHTMLOpenAccessArticleFacileSynthesisofMicro-MesoporousCopperPhyllosilicateSupportedonaCommercialCarrierandItsApplicationforCatalyticHydrogenationofNitro-GroupinTrinitrobenzenebyOlgaKirichenko,GennadyKapustin,IgorMishin,VeraNissenbaum,ElenaShuvalova,ElenaRedinaandLeonidKustovMolecules2022,27(16),5147;doi.org/10.3390/molecules(registering DOI)-12Aug2022AbstractDevelopmentofnovelCu-basedcatalystshasbecomeoneofthefrontiersinthecatalyticproductionofplatformchemicalsandinenvironmentprotection.However,theknownmethodsoftheirsynthesisaretoocomplicatedandresultinmaterialsthatcannotbeusedinstantlyascommercial[...]Readmore.DevelopmentofnovelCu-basedcatalystshasbecomeoneofthefrontiersinthecatalyticproductionofplatformchemicalsandinenvironmentprotection.However,theknownmethodsoftheirsynthesisaretoocomplicatedandresultinmaterialsthatcannotbeusedinstantlyascommercialcatalysts.Inthepresentwork,anovelmaterialhasbeensynthesizedbythefacilemethodofdeposition–precipitationusingthermalhydrolysisofurea.TheconditionsforCuphyllosilicateformationhebeenrevealed(molarratiourea:copper=10,92°C,8–11h).ThepreparedCu-basedmaterialswerestudiedbyTG–DTA,SEM,TEM,XRD,N2adsorptionandTPR-H2methods,anditwasfoundthatthematerialinvolvesnanoparticlesofmicro-mesoporouscopperphyllosilicatephasewithachrysocolla-likestructureinsidetheporesofacommercialmeso-macroporoussilicacarrier.Thechrysocolla-likephaseisfirstshowntobecatalyticallyactiveintheselectivereductionofthenitro-groupintrinitrobenzenetoanamino-groupwithmolecularhydrogen.Completeconversionoftrinitrobenzenewithahighyieldofamineshasbeenachievedinshorttimeunderrelativelymildconditions(170°C,1.3MPa)ofnitroarenehydrogenationoveracoppercatalyst.Fullarticle(ThisarticlebelongstotheSpecialIssueCatalysisbyHybridMaterials)9658;9660;ShowFiguresFigure1Figure2---Figure3---Figure4---Figure5---Figure6---Figure7---Figure8---Figure9---Figure10get_appsubjectViewonlineas:AbstractPeOpenAccessArticleAAC-IoT:AttributeAccessControlSchemeforIoTUsingLightweightCryptographyandHyperledgerFabricBlockchainbySuhairAlshehriandOmaimahBamasAppl.Sci.2022,12(16),8111;doi.org/10.3390/app(registering DOI)-12Aug2022AbstractTheInternetofThings(IoT)isanintegratedenvironmentasitmergesphysicalsmartobjectstotheInternetviawirelesstechnologiestosharedata.TheglobalconnectivityofIoTdevicesbringstheneedstoensuresecurityandprivacyfordataownersanddata[...]Readmore.TheInternetofThings(IoT)isanintegratedenvironmentasitmergesphysicalsmartobjectstotheInternetviawirelesstechnologiestosharedata.TheglobalconnectivityofIoTdevicesbringstheneedstoensuresecurityandprivacyfordataownersanddatausers.Inthispaper,anattribute-basedaccesscontrolschemeforIoT(AAC-IoT)usingHyperledgerFabric(HLF)blockchainisproposedtoaddressthesecuritychallenges.IntheAAC-IoTscheme,dataownersareregisteredandauthenticatedusingidentities,certificatesandsignatures.Datausers,however,areregisteredwithidentities,certificates,signaturesandphysicalunclonablefunction(PUF);thenacredencescoreiscomputedforuserstopredicttheoriginalityduringauthentication.Foraccesscontrol,attribute-basedaccesscontrol(ABAC)isused,andthenumberofattributesisselectedbasedonthesensitivityofthedata.Inaccordancewiththeattributescount,theaccesscontrolpoliciesaregenerated.Thenovelconceptofattributecountisdeterminedfromafuzzylogicmethodusingdatatypeandpreference.HyperledgerFabric(HLB)blockchainispresentedtomanemeta-dataandsecuritycredentialsfromdataownersanddatausers,respectively,usingalightweighthashingalgorithm.TheAAC-IoTmodelusingHLFblockchainisdevelopedwithJaprogramminglangueandiFogSimsimulator.Theperformancemetricsaremeasuredbasedonlatency,throughputandstoreoverhead,andtheresultsshowbetteroutcomethanthepreviousresearchwork.Fullarticle(ThisarticlebelongstotheSectionComputingandArtificialIntelligence)get_appsubjectViewonlineas:AbstractPeOpenAccessArticleNovelFullerEarth,RockPhosphate,andBiocharforPhytomanementofToxicMetalsinPollutedSoilsbyDaniyalSherBahadur,SamreenRiazAhmed,AltafHussainLahori,TanveerHussain,SofiaKhaliqueAlvi,SherazShafique,SadiaFatima,ViolaVambol,MonikaMierzwa-Hersztek,PreetaHinduja,SergijVambolandZengqiangZhangriculture2022,12(8),1216;doi.org/10.3390/riculture(registering DOI)-12Aug2022AbstractThepresentstudywasaimedtoassesstheefficacyofindividualandcombinedeffectsofnovelfullerearth,rockphosphate,andbiochar(grapefruitpeel)at1%doseonmaizeplantgrowth,soilchemicalpropertiesanduptakeoftoxicmetals(TMs),suchasCu,Zn,[...]Readmore.Thepresentstudywasaimedtoassesstheefficacyofindividualandcombinedeffectsofnovelfullerearth,rockphosphate,andbiochar(grapefruitpeel)at1%doseonmaizeplantgrowth,soilchemicalpropertiesanduptakeoftoxicmetals(TMs),suchasCu,Zn,Fe,andCd,bymaizeplantsowninKorangi(districtofKarachi,Pakistan)heilypollutedandKorangilesspolluted(K-HPandK-LP)soils.Theobtainedresultsindicatethatthedrybiomassofmaizecropincreasedby14.13%withcombined(FE1%+GBC1%)onK-HPsoiland18.24%withcombined(FE1%+GBC1%)effectsonK-LPsoil.ThemaximumimmobilizationofCu,Zn,Fe,andCdwasobservedby36%withGBC1%,11.90%withFE1%,98.97%withcombinedRP1%+GBC1%,51.9%withFE1%+GBC1%forK-HP,11.90%withFE1%,28.6%withFE1%,22.22%withRP1%+GBC1%,and57.05%withFE1%+GBC1%forK-LPsoil.Aftertheadditionofproposedsubstances,modificationofsoilOM,SOC,TOC,andpHlevelappearedthisleadtothechangesinthephyto-ailabilityofCu,Zn,Fe,andCdinmaizeplant.Itwasconcludedthattheapplicationofindividualandcombinedeffectsofnovelfullerearth,rockphosphate,andbiochar(grapefruitpeel)hepotentialtostabilizepollutantsfrommulti-metalpollutedsoilsforsafecropproduction.Fullarticle(ThisarticlebelongstotheSpecialIssueSoilOrganicMatterandItsRoleinSoilFertility)attachmentSupplementarymaterial:SupplementaryFile1(ZIP,135KiB)get_appsubjectViewonlineas:AbstractPeOpenAccessArticleWeldingFumeInstillationinIsolatedPerfusedMouseLungs—EffectsofZinc-andCopper-ContainingWeldingFumesbyJuliaKrabbe,ThomasKraus,HanifKrabbe,ChristianMartinandPatrickZieglerInt.J.Mol.Sci.2022,23(16),9052;doi.org/10.3390/ijms(registering DOI)-12Aug2022AbstractZinc-andcopper-containingweldingfumescancausesystemicinflammationafterexposureinhumans.Recentexvivostudiesheshownthattheobservedinflammationoriginatesfromexposedimmunecells.Invitrostudiesidentifiedthesolublefractionofmetalparticlesasthemaineffectors.Isolated[...]Readmore.Zinc-andcopper-containingweldingfumescancausesystemicinflammationafterexposureinhumans.Recentexvivostudiesheshownthattheobservedinflammationoriginatesfromexposedimmunecells.Invitrostudiesidentifiedthesolublefractionofmetalparticlesasthemaineffectors.Isolatedperfusedmouselungs(IPLs)wereperfusedandventilatedfor270min.Lungswereinstilledwithsalinesolution(control),weldingfumeparticlesuspension(WFs)orthesolublefractionoftheweldingfumes(SF-WFs).Bronchoalveolarlefluid(BALF)andperfusatesampleswereanalyzedforcytokinelevelsandlungtissuemRNAexpressionlevelswereanalyzedviaRT-PCR.AlllungsinstilledwithWFsdidnotcompletetheexperimentsduetoafatalreductionintidalvolume.Accordingly,IL-6andMPOlevelsweresignificantlyhigherinBALFofWFlungscomparedtothecontrol.IL-6andMPOmRNAexpressionlevelswerealsoincreasedforWFs.LungsinstilledwithSF-WFsonlyshowedmildreactionsintidalvolume,withBALFandmRNAexpressionlevelsnotsignificantlydifferingfromthecontrol.Zinc-andcopper-containingweldingfumeparticlesadverselyaffectIPLswheninstilled,asevidencedbythefatallossintidalvolumeandincreasedcytokineexpressionandsecretion.Theeffectsaremainlycausedbytheparticles,notbythesolublefraction.Fullarticle(ThisarticlebelongstotheSpecialIssueMyeloperoxidase)attachmentSupplementarymaterial:SupplementaryFile1(ZIP,1090KiB)get_appsubjectViewonlineas:AbstractPeOpenAccessArticleTheHPV16E7AffibodyasaNovelPotentialTherapeuticentforTreatingCervicalCancerIsLikelyInternalizedthroughDynaminandCeolin-1DependentEndocytosisbyQingyuanZhang,HuaZhu,ZhouyingCui,YuxiaoLi,JiayingZhuo,JingweiYe,ZhihuiZhang,ZhengLian,QianqianDu,Kong-NanZhao,LifangZhangandPengfeiJiangBiomolecules2022,12(8),1114;doi.org/10.3390/biom(registering DOI)-12Aug2022AbstractAffibodiestargetingintracellularproteinsheagreatpotentialtofunctionasidealtherapeuticents.However,littleisknownabouthowtheaffibodiesentertargetcellstointeractwithintracellulartargetproteins.WehepreviouslydevelopedtheHPV16E7affibody(ZHPV16E7384)forHPV16[...]Readmore.Affibodiestargetingintracellularproteinsheagreatpotentialtofunctionasidealtherapeuticents.However,littleisknownabouthowtheaffibodiesentertargetcellstointeractwithintracellulartargetproteins.WehepreviouslydevelopedtheHPV16E7affibody(ZHPV16E7384)forHPV16positivecervicalcancertreatment.Here,weexploredtheunderlyingmechanismsofZHPV16E7384andfoundthatZHPV16E7384significantlyinhibitedtheproliferationoftargetcellsandinducedaG1/Sphasecellcyclearrest.Furthermore,ZHPV16E7384treatmentresultedintheupregulationofretinoblastomaprotein(Rb)anddownregulationofphosphorylatedRb(pRb),E2F1,cyclinD1,andCDK4inthetargetcells.Moreover,treatmentwithdynaminortheceolin-1inhibitornotonlysignificantlysuppressedtheinternalizationofZHPV16E7384intotargetcellsbutalsoreversedtheregulationofcellcyclefactorsbyZHPV16E7384.Overall,theseresultsindicatethatZHPV16E7384waslikelyinternalizedspecificallyintotargetcellsthroughdynamin-andceolin-1mediatedendocytosis.ZHPV16E7384inducedthecellcyclearrestintheG1/SphaseatleastpartiallybyinterruptingHPV16E7bindingtoanddegradingRb,subsequentlyleadingtothedownregulationofE2F1,cyclinD1,CDK4,andpRb,whichultimatelyinhibitedtargetcellproliferation.ThesefindingsprovidearationaleofusingZHPV16E7384toconductaclinicaltrialfortargettherapyincervicalcancer.Fullarticleget_appsubjectViewonlineas:AbstractPeOpenAccessArticleApplyingMultipleFunctionalConnectivityFeaturesinGCNforEEG-BasedHumanIdentificationbyWenliTian,MingLi,XiangyuJuandYadongLiuBrainSci.2022,12(8),1072;doi.org/10.3390/brainsci(registering DOI)-12Aug2022AbstractEEG-basedhumanidentificationhasgainedawiderangeofattentionduetothefurtherincreaseindemandforsecurity.Howtoimprovetheaccuracyofthehumanidentificationsystemisanissueworthyofattention.Usingmorefeaturesinthehumanidentificationsystem[...]Readmore.EEG-basedhumanidentificationhasgainedawiderangeofattentionduetothefurtherincreaseindemandforsecurity.Howtoimprovetheaccuracyofthehumanidentificationsystemisanissueworthyofattention.Usingmorefeaturesinthehumanidentificationsystemisapotentialsolution.However,toomanyfeaturesmaycauseoverfitting,resultinginthedeclineofsystemaccuracy.Inthiswork,thegraphconvolutionalneuralnetwork(GCN)wasadoptedforclassification.MultiplefeatureswerecombinedandutilizedasthestructurematrixoftheGCN.Becauseoftheconstantsignalmatrix,thetrainingparameterswouldnotincreaseasthestructurematrixgrows.Weevaluatedtheclassificationaccuracyonaclassicpublicdataset.Theresultsshowedthatutilizingmultiplefeaturesoffunctionalconnectivity(FC)canimprovetheaccuracyoftheidentityauthenticationsystem,thebestresultsofwhichareat98.56%.Inaddition,ourmethodsshowedlesssensitivitytochannelreduction.ThemethodproposedinthispapercombinesdifferentFCsandreacheshighclassificationaccuracyforunpreprocesseddata,whichinspiresreducingthesystemcostintheactualhumanidentificationsystem.Fullarticle(ThisarticlebelongstotheSectionComputationalNeuroscienceandNeuroinformatics)get_appsubjectViewonlineas:AbstractPeOpenAccessFeaturePaperReviewMinIONNanoporeSequencingAcceleratesProgresstowardsUbiquitousGeneticsinWaterResearchbyDidWerner,KishorAcharya,AdrianBlackburn,RixiaZan,JidapaPlaimart,BenAllen,ShaabanMrishoMgana,ShadrackMwitaSabai,FranellaFrancosHalla,SaidManenoMassawa,AlemsegedTamiruHaile,AndualemMekonnenHiruy,JemilaMohammed,SoydoaVinitnantharat,ThunchanokThongsamer,KalyanPantha,CesarRossasMotaFilhoandBrunaCoelhoLopesWater2022,14(16),2491;doi.org/10.3390/w(registering DOI)-12Aug2022AbstractIn2014,OxfordNanoporeTechnologies(ONT)introducedanaffordableandportablesequencercalledMinION.Wereviewedemergingapplicationsinwaterresearchandassessedprogressmadewiththisplatformtowardsubiquitousgenetics.With>99%singsinupfrontcostsascomparedtoconventionalplatforms,the[...]Readmore.In2014,OxfordNanoporeTechnologies(ONT)introducedanaffordableandportablesequencercalledMinION.Wereviewedemergingapplicationsinwaterresearchandassessedprogressmadewiththisplatformtowardsubiquitousgenetics.With>99%singsinupfrontcostsascomparedtoconventionalplatforms,theMinIONputsequencingcapacityintothehandsofmanyresearchersandenablednovelapplicationswithdiverseremits,includingincountrieswithoutuniversalaccesstosafewaterandsanitation.However,torealizetheMinION’sfabledportability,alltheauxiliaryequipmentitemsforbiomassconcentration,geneticmaterialextraction,cleanup,quantification,andsequencinglibrarypreparationalsoneedtobelightweightandaffordable.OnlyafewstudiesdemonstratedfullyportableworkflowsbyusingtheMinIONonboardadivingvessel,anoceanographicresearchship,andatsewetreatmentworks.LowernanoporesequencingreadaccuracyascomparedtoalternativeplatformscurrentlyhindersMinIONapplicationsbeyondresearch,andinclusionofpositiveandnegativecontrolsshouldbecomestandardpractice.ONT’sEPI2MEplatformisamajorsteptowardsuser-friendlybioinformatics.However,noconsensushasyetemergedregardingthemostappropriatebioinformaticpipeline,whichhindersintercomparisonofstudyresults.Processing,storing,andinterpretinglargedatasetsremainsamajorchallengeforubiquitousgeneticsanddemocratizingsequencingapplications.Fullarticle(ThisarticlebelongstotheSpecialIssueFieldMethodsforWaterQualitySurveying)9658;9660;ShowFiguresGraphicalabstractget_appsubjectViewonlineas:AbstractPeOpenAccessArticleLarge-Scale3DMulti-StoryEnterpriseLayoutDesigninaNewTypeofIndustrialParkinChinabyXueminLiu,GuozhongHuang,XuehongGao,HaoxuanLi,ShengnanOuandIbrahimM.HezamAppl.Sci.2022,12(16),8110;doi.org/10.3390/app(registering DOI)-12Aug2022AbstractInthenew-typeclusteredindustrialpark,thecloserdistancebetweenenterprisesleadstoriskgregation,andthelayoutofenterprisesaffectsthesafetyandeconomyofthepark.However,previousstudiesheoftenpaidinsufficientattentiontosafety,andfewstudiesheconsidered[...]Readmore.Inthenew-typeclusteredindustrialpark,thecloserdistancebetweenenterprisesleadstoriskgregation,andthelayoutofenterprisesaffectsthesafetyandeconomyofthepark.However,previousstudiesheoftenpaidinsufficientattentiontosafety,andfewstudiesheconsideredparkprofits.Toaddressthisissue,abi-levelthree-dimensionallayoutoptimizationmodelwasproposedtominimizetheoverallassociationriskoftheparkandmaximizetherentalprofit.Inparticular,thisarticleexplainedtheenterpriseassociationrisksandprovidedcalculationformulas,consideringmultiplerisktypes.Tosolvetheproposednonlinearmodel,aspecificvariableconversionmethodwaspresentedtoreducetheproblemscale.Subsequently,animprovedgeneticalgorithmwasdevelopedandappliedtoobtainthelayoutresults.Furthermore,acasestudyofanindustrialparkwasconducted,andthecomputationalresultsindicatedthevalidityofthemodelandmethods.Finally,twodifferentscenarioswereimplemented,andcriticalparametersweretestedtoprovidevaluablemanementinsights.Fullarticle(ThisarticlebelongstotheSpecialIssueAdvancedManufacturingTechnologies:DevelopmentandProspect)get_appsubjectViewonlineas:AbstractPeOpenAccessArticleImprovedDDoSDetectionUtilizingDeepNeuralNetworksandFeedforwardNeuralNetworksasAutoencoderbyAhmedLatifYaser,HamdyM.MousaandMahmoudHusseinFutureInternet2022,14(8),240;doi.org/10.3390/fi(registering DOI)-12Aug2022AbstractSoftware-definednetworking(SDN)isaninnovativenetworkparadigm,offeringsubstantialcontrolofnetworkoperationthroughanetworkx2019;sarchitecture.SDNisanidealplatformforimplementingprojectsinvolvingdistributedapplications,securitysolutions,anddecentralizednetworkadministrationinamultitenantdatacenterenvironmentdueto[...]Readmore.Software-definednetworking(SDN)isaninnovativenetworkparadigm,offeringsubstantialcontrolofnetworkoperationthroughanetwork’sarchitecture.SDNisanidealplatformforimplementingprojectsinvolvingdistributedapplications,securitysolutions,anddecentralizednetworkadministrationinamultitenantdatacenterenvironmentduetoitsprogrammability.Asitsuserapidlyexpands,networksecuritythreatsarebecomingmorefrequent,leadingSDNsecuritytobeofsignificantconcern.Machine-learning(ML)techniquesforintrusiondetectionofDDoSattacksinSDNnetworksutilizestandarddatasetsandfailtocoverallclassificationaspects,resultinginunder-covereofattackdiversity.Thispaperproposesahybridtechniquetorecognizedenial-of-service(DDoS)attacksthatcombinedeeplearningandfeedforwardneuralnetworksasautoencoders.Twodatasetswereanalyzedforthetrainingandtestingmodel,firststaticallyandtheniteratively.Theauto-encodingmodelisconstructedbystackingtheinputlayerandhiddenlayerofself-encodingmodels’layerbylayer,witheachself-encodingmodelusingahiddenlayer.Toevaluateourmodel,weuseathree-partdatasplit(train,test,andvalidate)ratherthanthecommontwo-partsplit(trainandtest).Theresultingproposedmodelachievedahigheraccuracyforthestaticdataset,whereforISCX-IDS-2012dataset,accuracyreachedahighof99.35%intraining,99.3%invalidationand99.99%inprecision,recall,andF1-score.fortheUNSW2018dataset,theaccuracyreachedahighof99.95%intraining,0.99.94%invalidation,and99.99%inprecision,recall,andF1-score.Inaddition,themodelachievedgreatresultswithadynamicdataset(usinganemulator),reachingahighof97.68%inaccuracy.Fullarticle(ThisarticlebelongstotheSectionCybersecurity)get_appsubjectViewonlineas:AbstractPeOpenAccessArticleIcingTimePredictionModelofPementBasedonanImprovedSVRModelwithResponseSurfaceApproachbyLingxiaoShangguan,YunfeiYin,QingtaoZhang,QunLiu,WeiXieandZejiaoDongAppl.Sci.2022,12(16),8109;doi.org/10.3390/app(registering DOI)-12Aug2022AbstractPementicingimposesagreatthreattodrivingsafetyandimpactstheefficiencyoftheroadtransportationsystemincoldregions.Thishasattractedresearchpredictingpementicingtimetosolvetheproblemsbroughtaboutbyicing.Differentmodelshebeenproposedin[...]Readmore.Pementicingimposesagreatthreattodrivingsafetyandimpactstheefficiencyoftheroadtransportationsystemincoldregions.Thishasattractedresearchpredictingpementicingtimetosolvetheproblemsbroughtaboutbyicing.Differentmodelshebeenproposedinthepastdecadestopredictpementicing,withinwhichsupportvectorregression(SVR)isawidelyusedalgorithmforcalibratinghighlynonlinearrelationships.ThispaperpresentsahybridimprovedSVRalgorithmtopredictthetimeofpementicingwithanenhancementoperationbyresponsesurfacemethod(RSM)andparticleswarmoptimization(PSO).RSMisusedtoincreasethenumberofinputdatacollectedonsite.Basedonthat,theoptimalSVRmodelisestablishedbyoptimizingthekernelfunctionparametersandpenaltycoefficientwiththeparticleswarmoptimization(PSO)algorithm.ThehybridimprovedSVRiscomparedwithSVR,PSO-SVR,andRSM-PSOforcoefficientofdetermination(R2),meanabsoluteerror,meanabsolutepercenteerror,androotmeansquareerrortochecktheeffectivenessofPSOandRSMinoptimizingSVR.TheresultsshowthatthecombinationoftwomethodsinthehybridimprovedalgorithmhasabetteroptimizationcapabilitywithR2of0.9655and0.9318inatrainsetandtestset,respectively,whichoutperformsPSO-SVR,RSM-SVR,andSVR.Inaddition,theR2ofthehybridimprovedSVRandPSO-SVRbothreachtheoptimalfitnessvalueapproximatelyattheiterationof20,whichsuggeststhatconvergencecapacityremainsrelativelyconstantwiththepredictiveaccuracybeingimproved.Fullarticle(ThisarticlebelongstotheSectionTransportationandFutureMobility)get_appsubjectViewonlineas:AbstractPeOpenAccessArticleAnEmpiricalResearchofStudents’PerceptionsRegardingM-CommerceAcquisitionsduringtheCOVID-19PandemicbyCătălinGrădinaru,Ștefan-AlexandruCatană,SorinGeorgeTomaandAndreeaBarbuSustainability2022,14(16),;doi.org/10.3390/su6(registering DOI)-12Aug2022AbstractTheemergenceandspreadoftheCOVID-19pandemichesignificantlychangedthewaycommerceprocesseshebeencarriedoutoverthelasttwoyears.ConsideringthedevelopmentoftheInternetandtheincreasinguseofdigitalizationinrecentyears,electroniccommercehasbecome[...]Readmore.TheemergenceandspreadoftheCOVID-19pandemichesignificantlychangedthewaycommerceprocesseshebeencarriedoutoverthelasttwoyears.ConsideringthedevelopmentoftheInternetandtheincreasinguseofdigitalizationinrecentyears,electroniccommercehasbecomeanimportantpartoftheglobalretailframework.Accordingly,mobilecommercehasemergedanddevelopedthroughvariousapplicationsasamodernalternativeforbuyingandsellingproductsand/orservicesusingonlymobiledevices.Thispaperaimstoidentifyandanalyzeseveralkeyfactorsthatinfluencestudents’perceptionsregardingm-commerceacquisitions.Italsoattemptstoillustratesomeofthemainadvantesanddisadvantesofm-commerceacquisitionandtoinvestigateitsinfluenceonstudents’perceptionsregardingm-commercepurchases.Inordertoachievetheseobjectives,theauthorsgathereddatathroughaquantitativeresearchmethodbyusingaquestionnaire.Thedatawereanalyzedandinterpretedthroughafactorialanalysisthatusesthepresentationofthemaincomponentsasanextractionmethod,withthevarimaxrotationmethodadoptingKaisernormalization,andprocessedwithSPSSstatisticalsoftware.Theresultsofthisresearchshowthatmobile-commerceacquisitionsareinfluencedbyfivefactors(social,political-legislative,technological,financial,andeconomic).Inthisrespect,socialandpolitical-legislativefactorsinfluence,atamoderatelevel,thegeneralfrequencyofm-commerceacquisition,whiletheeconomicfactordoesnotinfluencethegeneralfrequencyofm-commercepurchases.Thestudyprovidesatheoreticalmodelthattakesintoaccountthefactorsthatinfluencem-commerceacquisition,includingtheinfluenceoftheperceivedadvantesanddisadvantesonm-commercepurchase.Thepaperalsodisplaysthewayinwhichtheseitemsinfluencestudents’perceptiononm-commerceacquisitions.Fullarticleget_appsubjectViewonlineas:AbstractPeOpenAccessArticleLEDLightingrosystemwithParallelPowerSupplyfromPhotovoltaicModulesandaPowerGridbyPelTikhonov,KonstantinMorenko,ArseniySychov,VadimBolshev,AlexanderSokolovandAlexanderSmirnovriculture2022,12(8),1215;doi.org/10.3390/riculture(registering DOI)-12Aug2022AbstractThepaperconsiderstheoperationofanLEDlightingsystemwithaparallelpowersupplyfromphotovoltaicmodulesandapowergrid.Suchsystemsaresupposedtobewidelyapplicableinpremiseswithlimitednaturallighting,particularlyrosystemswhereartificiallightofa[...]Readmore.ThepaperconsiderstheoperationofanLEDlightingsystemwithaparallelpowersupplyfromphotovoltaicmodulesandapowergrid.Suchsystemsaresupposedtobewidelyapplicableinpremiseswithlimitednaturallighting,particularlyrosystemswhereartificiallightofacertainspectrumisspecificallyrequiredtoensureefficientplantgrowth.ThepaperpresentstheschemeofthedevelopedLEDlightingsystem,aswellasanassembledprototypecontainingasingle36-wattlamp.ThedataoftheexperimentalstudyareprovidedonthedevelopedLEDlightingsystemusingthedevelopedmonitoringsystem.Theexperimentalstudydemonstratesanefficientpowertake-offandthereliabilityoftheproposedschemetocompetentlyselectthecharacteristicsandcircuitsolutionsfortheconverterofvoltefromthePVmodule.TheproposedLEDsystemallowssimplificationofthePVsystembyeliminatingcircuitswithaninverterandstoredevices,hencesignificantlyreducingthecostofthephotovoltaicsystems.Likewise,suchasimplicityhasapositiveeffectonPVsystemreliability,whichbenefitsthecostaswell.Fullarticle(ThisarticlebelongstotheSpecialIssueAdvancesinriculturalEngineeringTechnologiesandApplication)get_appsubjectViewonlineas:AbstractPeOpenAccessArticleApplicationofBiofluorescentParticleCountersforReal-TimeBioburdenControlinAsepticCleanroomManufacturingbyDetlefBehrens,JensSchaefer,CorneliaM.KeckandFrankE.RunkelAppl.Sci.2022,12(16),8108;doi.org/10.3390/app(registering DOI)-12Aug2022AbstractThisexperimentalstudyexaminestheuseofarealtimeviableparticlecounterinpharmaceuticalcleanroomoperationsunderISOclass8/Annex1ClassCx2018;inoperationx2019;conditions.Theusedmeasuringsystem,abiofluorescentparticlecounter(BFPC),continuouslydetectedparticles>1.0xB5;maswell[...]Readmore.ThisexperimentalstudyexaminestheuseofarealtimeviableparticlecounterinpharmaceuticalcleanroomoperationsunderISOclass8/Annex1ClassC‘inoperation’conditions.Theusedmeasuringsystem,abiofluorescentparticlecounter(BFPC),continuouslydetectedparticles>1.0µmaswellasmicrobecarrying(viable)particles(MCPs).Inaddition,classicairsamplersfortheevaluationofColonyFormingUnits(CFU)wereinstalledtoenableacomparisonofcounter-providedvalueswithclassic,ar-basedmethodsofmicrobialairsamplingrequiredbyregulatoryguidelines.Atestroomcomparabletotypicalcleanroomsinthepharmaceuticalindustrywasoperatedunderthreedifferentairchangerates(ACR).AttheseACRs,theoperatorsworethreedifferentgarments.Withtestrepetition,18experimentswereconductedsimulatingdifferentpharmaceuticalprocessconditions.TheresultsshowcorrelationsofmeasuredparticlestoMCPsandMCPstoCFUs.Furthermore,albeitanindustry-wideusedandregulatoryacceptedminimumARCvalueof20h−1,thestudyresultsindicatethatanACRof10h−1iscapableofkeepingcleanroomswithinregulatorylimitsforparticlesandCFUs,andthusprovidestheopportunitytoseenergyforcleanroomoperations.TheimplementationofrealtimeviableparticlecounterscanbeusedtoachieveaqualityadvanteforISOclass8cleanroomsforacontinuous,documentedcontrolofthecleanroomstatus,andthusenableareductionofACRswiththeaimofenergysing.Furtherlong-termstudiesshouldvalidatethis.Fullarticleget_appsubjectViewonlineas:AbstractPeOpenAccessArticleGeo-LocationMethodforImesofDamedRoadsbyWenboZhang,JueQu,WeiWang,JunHuandJieLiElectronics2022,11(16),2530;doi.org/10.3390/electronics(registering DOI)-12Aug2022AbstractDuetothelargedifferencebetweennormalconditionsanddamedroadimes,geo-locationindamedareasoftenfailsduetoocclusionordametobuildingsandiconicsigneintheime.Inordertostudytheinfluenceofpost-warbuildingandlandmarkdame[...]Readmore.Duetothelargedifferencebetweennormalconditionsanddamedroadimes,geo-locationindamedareasoftenfailsduetoocclusionordametobuildingsandiconicsigneintheime.Inordertostudytheinfluenceofpost-warbuildingandlandmarkdameconditionsonthegeolocationresultsoflocalizationalgorithms,andtoimprovethegeolocationeffectofsuchalgorithmsunderdamedconditions,thispaperusedinformativereferenceimesandkeypointselection.Aimingatthenegativeeffectsofocclusionandlandmarkbuildingdameintheretrievalprocess,aretrievalmethodcalledreliability-andrepeatability-baseddeeplearningfeaturepointsisproposed.Inordertoverifytheeffectivenessoftheabovealgorithm,thispaperconstructedadatasetconsistingofurban,ruralandtechnologicalparksandotherroadsegmentsasatrainingsettogenerateadatabase.Itconsistsof11,896referenceimes.Consideringthecostofdamedlandmarks,anartificiallygeneratedmethodisusedtoconstructimesofdamedlandmarkswithdifferentdameratiosasatestset.Experimentsshowthatthedatabaseoptimizationmethodcaneffectivelycompressthestorecapacityofthefeatureindexandcanalsospeedupthepositioningspeedwithoutaffectingtheaccuracyrate.Theproposedimeretrievalmethodoptimizesfeaturepointsandfeatureindicestomakethemreliableainstdamedterrainandimes.Theimprovedalgorithmimprovedtheaccuracyofgeo-locationfordamedroads,andthemethodbasedondeeplearninghasahighereffectonthegeo-locationofdamedroadsthanthetraditionalalgorithm.Furthermore,wefullydemonstratedtheeffectivenessofourproposedmethodbyconstructingamulti-segmentroadimedataset.Fullarticle(ThisarticlebelongstotheTopicComputerVisionandImeProcessing)attachmentSupplementarymaterial:SupplementaryFile1(ZIP,2207KiB)get_appsubjectViewonlineas:AbstractPeOpenAccessSystematicReviewComplicationsofRoboticVideo-AssistedThoracoscopicSurgeryComparedtoOpenThoracotomyforResectableNon-SmallCellLungCancerbyOscarZhang,RobertAlzul,MatheusCarelli,FrancaMelfi,DidTianandChristopherCaoJ.Pers.Med.2022,12(8),1311;doi.org/10.3390/jpm(registering DOI)-12Aug2022Abstract(1)Background:Conventionalopenthoracotomyhasbeentheacceptedsurgicaltreatmentforresectablenon-smallcelllungcancer.However,newer,minimallyinvasiveapproaches,suchasroboticsurgery,hedemonstratedsimilarsafetyandefficacywithpotentiallysuperiorperi-operativeoutcomes.Thepresentstudyaimedtoquantitatively[...]Readmore.(1)Background:Conventionalopenthoracotomyhasbeentheacceptedsurgicaltreatmentforresectablenon-smallcelllungcancer.However,newer,minimallyinvasiveapproaches,suchasroboticsurgery,hedemonstratedsimilarsafetyandefficacywithpotentiallysuperiorperi-operativeoutcomes.Thepresentstudyaimedtoquantitativelyassesstheseoutcomesthroughameta-analysis.(2)Methods:Asystematicreviewwasperformedusingelectronicdatabasestoidentifyalloftherelevantstudiesthatcomparedroboticsurgerywithopenthoracotomyfornon-smallcelllungcancer.Pooleddataontheperi-operativeoutcomeswerethenmeta-analyzed.(3)Results:Twenty-twostudiesinvolving12,061patientswhounderwentroboticlungresectionand92,411patientswhounderwentopenthoracotomywereincludedforanalysis.Mortalityratesandlengthofhospitalstayweresignificantlylowerinpatientswhounderwentroboticresection.Comparedtoopenthoracotomy,roboticsurgerywasalsoassociatedwithsignificantlylowerratesofoverallcomplications,includingatrialarrhythmia,post-operativebloodtransfusions,pneumoniaandatelectasis.However,theoperativetimesweresignificantlylongerwithroboticlungresection.(4)Conclusion:Thepresentmeta-analysisdemonstratedsuperiorpost-operativemorbidityandmortalityoutcomeswithroboticlungresectioncomparedtoopenthoracotomyfornon-smallcelllungcancer.Fullarticle(ThisarticlebelongstotheSpecialIssueAdoptionofRoboticsinThoracicSurgery)attachmentSupplementarymaterial:SupplementaryFile1(ZIP,934KiB)get_appsubjectViewonlineas:AbstractPeOpenAccessArticleZinc(II),Palladium(II),andMetal-FreePhthalocyaninesBearingNipin-FunctionalizedSubstituentsainstCandidaaurisandSelectedMultidrug-ResistantMicrobesbyDanielZiental,DariuszT.Mlynarczyk,EmilKolasinski,EmreGüzel,JolantaDlugaszewska,ŁPer favore aspetta... ClouddichiaratoukaszPopenda,StefanJurga,TomaszGoslinskiandLukaszSobottaPharmaceutics2022,14(8),1686;doi.org/10.3390/pharmaceutics(registering DOI)-12Aug2022AbstractDuetotherapidlyincreasingproblemofantibioticresistanceinrecentyears,theuseofphthalocyaninesasphotosensitizerswiththeirsuperiorpropertiesinphotodynamicantimicrobialtherapy(PACT)applicationshasbecomeimportant.Inthisstudy,mnesium(II)1,4,8,11,15,18,22,25-octakis(4-[4-butoxycarbonylphenoxy]butyloxy)phthalocyaninewasusedinthedemetalationreactionin[...]Readmore.Duetotherapidlyincreasingproblemofantibioticresistanceinrecentyears,theuseofphthalocyaninesasphotosensitizerswiththeirsuperiorpropertiesinphotodynamicantimicrobialtherapy(PACT)applicationshasbecomeimportant.Inthisstudy,mnesium(II)1,4,8,11,15,18,22,25-octakis(4-[4-butoxycarbonylphenoxy]butyloxy)phthalocyaninewasusedinthedemetalationreactionintrifluoroaceticacid,andsubsequentlysubjectedtometalationreactionindimethylformamidewithzinc(II)acetateandbis(benzonitrile)palladium(II)chloridetowardszinc(II)andpalladium(II)derivatives.Threephthalocyanines,includingademetalatedoneaswellastwometalated,inthecorewithzinc(II)andpalladium(II)werecharacterizedusing1Dand2DNMRspectroscopyandmassspectrometry.Inaddition,allmacrocyclesweresubjectedtoabsorptionandemissionstudiesaswellasphotostabilitytests.Inaphotochemicalstudy,zinc(II)andpalladium(II)phthalocyaninecomplexesappearedtobeefficientsingletoxygengenerators.Therewerenotedquantumyieldsofsingletoxygengenerationforzinc(II)phthalocyaninederivativeinDMFandDMSOat0.55and0.72,whereasforpalladium(II)complexat0.73and0.77,respectively.Liposomalformulationsofphthalocyaninederivativeswereprepared,andtheiractivitywasevaluatedainstabroadspectrumofantibiotic-resistantmicroorganisms,suchasmethicillin-resistantStaphylococcusaureus(MRSA),Escherichiacoli(ESBL+),Candidaalbicansresistanttofluconazole,C.auris,andainstdermatophytes.Phthalocyaninepalladium(II)complexshowedthehighestbactericidalactivityainstallantibiotic-resistantmicroorganisms,includingreducingC.aurisgrowthat3.54log.Fullarticle(ThisarticlebelongstotheSpecialIssueAntimicrobialSonodynamicandPhotodynamicTherapies)9658;9660;ShowFiguresGraphicalabstractget_appsubjectViewonlineas:AbstractPeOpenAccessReviewInfluenceofGut–LiverAxisonPortalHypertensioninAdvancedChronicLiverDisease:TheGutMicrobiomeAsANewProtonistinTherapeuticManementbyFrancescoSantopaolo,GaetanoCoppola,LuciaGiuli,AntonioGasbarriniandFrancescaRomanaPonzianiMicrobiol.Res.2022,13(3),539-555;doi.org/10.3390/microbiolres(registering DOI)-12Aug2022AbstractClinicallysignificantportalhypertensionisassociatedwithmostcomplicationsofadvancedchronicliverdisease(ACLD),includingvaricealbleeding,ascites,spontaneousbacterialperitonitis,hepatorenalsyndrome,andhepaticencephalopathy.GutdysbiosisisahallmarkofACLDwithportalhypertensionandconsistsoftheovergrowthof[...]Readmore.Clinicallysignificantportalhypertensionisassociatedwithmostcomplicationsofadvancedchronicliverdisease(ACLD),includingvaricealbleeding,ascites,spontaneousbacterialperitonitis,hepatorenalsyndrome,andhepaticencephalopathy.GutdysbiosisisahallmarkofACLDwithportalhypertensionandconsistsoftheovergrowthofpotentiallypathogenicbacteriaandadecreaseinautochthonousbacteria;additionally,congestionmakestheintestinalbarriermorepermeabletobacteriaandtheirproducts,whichcontributestothedevelopmentofcomplicationsthroughinflammatorymechanisms.Thisreviewsummarizescurrentknowledgeontheroleofthegut–liveraxisinthepathogenesisofportalhypertension,withafocusontherapiestargetingportalhypertensionandthegutmicrobiota.Themodulationofthegutmicrobiotaonseverallevelsrepresentsamajorchallengeintheupcomingyears;in-depthcharacterizationofthemolecularandmicrobiologicalmechanismslinkingthegut–liveraxistoportalhypertensioninabidirectionalrelationshipcouldpethewaytotheidentificationofnewtherapeutictargetsforinnovativetherapiesinthemanementofACLD.Fullarticleget_appsubjectViewonlineas:AbstractPeOpenAccessReviewAutophy,AcutePancreatitisandtheMetamorphosesofaTrypsinogen-ActivatingOrganellebySvetlanaVoronina,MichaelChvanov,FrancescaDeFeri,UlrikeMayer,TomWileman,DidCriddleandAlexeiTepikinCells2022,11(16),2514;doi.org/10.3390/cells(registering DOI)-12Aug2022AbstractRecentstudieshehighlightedtheimportanceofautophyandparticularlynon-canonicalautophyinthedevelopmentandprogressionofacutepancreatitis(afrequentdiseasewithconsiderablemorbidityandsignificantmortality).Animportantearlyeventinthedevelopmentofacutepancreatitisistheintrapancreaticactivation[...]Readmore.Recentstudieshehighlightedtheimportanceofautophyandparticularlynon-canonicalautophyinthedevelopmentandprogressionofacutepancreatitis(afrequentdiseasewithconsiderablemorbidityandsignificantmortality).Animportantearlyeventinthedevelopmentofacutepancreatitisistheintrapancreaticactivationoftrypsinogen,(i.e.,formationoftrypsin)leadingtotheautodigestionoftheorgan.Anotherprominentphenomenonassociatedwiththeinitiationofthisdiseaseisvacuolisationandspecificallytheformationofgiantendocyticvacuolesinpancreaticacinarcells.Theseorganellesdevelopinacinarcellsexposedtoseveralinducersofacutepancreatitis(includingtaurolithocholicacidandhighconcentrationsofsecretoguescholecystokininandacetylcholine).Notably,earlytrypsinogenactivationoccursintheendocyticvacuoles.Thesetrypsinogen-activatingorganellesundergoactivation,long-distancetrafficking,andnon-canonicalautophy.Inthisreview,wewilldiscusstheroleofautophyinacutepancreatitisandparticularlyfocusontherecentlydiscoveredLAP-likenon-canonicalautophy(LNCA)ofendocyticvacuoles.Fullarticle(ThisarticlebelongstotheSpecialIssueMembraneDynamicsandMolecularMechanismsduringAutophosomeBiogenesisandMaturation)get_appsubjectViewonlineas:AbstractPeOpenAccessArticleANovelLow-CostBio-SorbentPreparedfromCrispPersimmonPeelbyLow-TemperaturePyrolysisforAdsorptionofOrganicDyesbyLu-QingXie,Xin-YuJiangandJin-GangYuMolecules2022,27(16),5160;doi.org/10.3390/molecules(registering DOI)-12Aug2022AbstractInordertoproperlyreusefoodwasteandremovevariouscontaminantsfromwastewater,thedevelopmentofgreen,sustainableandcleantechnologieshasdemonstratedpotentialintheefficientinhibitionofsecondarypollutiontotheenvironment.Inthisstudy,aneconomicalandgreenmethodwas[...]Readmore.Inordertoproperlyreusefoodwasteandremovevariouscontaminantsfromwastewater,thedevelopmentofgreen,sustainableandcleantechnologieshasdemonstratedpotentialintheefficientinhibitionofsecondarypollutiontotheenvironment.Inthisstudy,aneconomicalandgreenmethodwasusedtopreparebiocharfromcrisppersimmonpeel(CPP)usingflash-vacuumpyrolysisatdifferenttemperatures(200–700°C;referredtoasCPP200–CPP700).CPP200hashighpolarity,lowaromaticityandhighoxygen-containingfunctionalgroupsthatexhibitsuperiorMBadsorptioncapabilities.CPP200thatwaspreparedatarelativelylowtemperatureof200°Cexhibitedahighadsorptioncapacityof59.72mg/gtowardmethyleneblue(MB),whichwasrelativelyhigherthanthatforalizarinyellowR(4.05mg/g)andneutralred(39.08mg/g),indicatingthatCPP200possessesahigheradsorptionselectivityforcationicdyes.KineticsinvestigationrevealedthatthekineticdataofCPP200fortheadsorptionofMBwasbetterfittedbyalinearpseudo-second-ordermodel.IsothermalstudiesindicatedthatthelinearLangmuirmodelwasmoresuitablefordescribingtheadsorptionprocess.TheadsorptionthermodynamicsillustratedthattheadsorptionofMBontoCPP200wasspontaneousandendothermic.EDSandIRanalysesofCPP200forbothpre-andpost-adsorptionofMBshowedthatelectrostaticinteractionsbetweenoxygen-containinggroupsonbiocharandtargetMBdominatedtheadsorptionprocedure,inadditiontohydrogenbondinginteractions.ReusabilitytestsconfirmedtheexcellentregenerationcharacteristicsofCPP200,indicatingthatCPP200maybeusedasagreen,sustainable,highlyefficientandrecyclableadsorbentfortheselectiveremovalofcationicorganicdyes.Fullarticleget_appsubjectViewonlineas:AbstractPeOpenAccessArticleAMetallicFractureEstimationMethodUsingDigitalImeCorrelationbyZiranWu,YanHan,BumengLiang,GuichuWu,ZhizhouBaoandWeifeiQianProcesses2022,10(8),1599;doi.org/10.3390/pr(registering DOI)-12Aug2022AbstractThispaperproposesametallicfractureestimationmethodthatcombinesdigitalimecorrelationandconvolutionalneuralnetworks,basedonaproventheorythatthestraindistributionofacomponentchangeswhenacrackoccursinastructure.Byusingdigitalimecorrelation,the[...]Readmore.Thispaperproposesametallicfractureestimationmethodthatcombinesdigitalimecorrelationandconvolutionalneuralnetworks,basedonaproventheorythatthestraindistributionofacomponentchangeswhenacrackoccursinastructure.Byusingdigitalimecorrelation,themethodachievesnoncontactandnondestructivesensing,aswellashighinterferenceimmunity.Weutilizeadigitalimecorrelationsystemtoproducestraindistributiongraphsthatreflectoccurrencesandpropationsoffracturesduringfatigueprocesses.Adeepresidualnetwork(ResNet)regressionmodelistrainedbycorrelatingstraindistributiongraphswiththecorrespondingfracturelengths,sothatthefracturepropationconditioncanbeestimatedbydatafromdigitalimecorrelation.Intheexperiment,accordingtotheAmericanSocietyforTestingMaterials(ASTM)standards,wefabricateasetofaluminumspecimensandperformfatiguetestswithdataacquisitionbydigitalimecorrelation.Finally,weobtainacracklengthestimationmeanabsoluteerrorof0.0077mm,or0.26%ofthemeasuringrange.Theresultsshowtheprecision,aswellasthepracticality,oftheproposedmethod.Fullarticle(ThisarticlebelongstotheSectionAutomationControlSystems)attachmentSupplementarymaterial:SupplementaryFile1(ZIP,591KiB)get_appsubjectViewonlineas:AbstractPeOpenAccessArticleMechanisticInsightintotheEnzymaticInhibitionofβ-AmyrinainstMycobacterialRv1636:InSilicoandInVitroApproachesbyMdAmjadBeg,Sadaf,AnasShamsi,SibasisSahoo,MohdYousuf,MohammadZeeshanNajm,YahyaAhmadAlmutawif,AsimulIslam,AbdulazizA.AloliqiandFareedaAtharBiology2022,11(8),1214;doi.org/10.3390/biology(registering DOI)-12Aug2022AbstractMycobacteriumtuberculosishasseentremendoussuccessasithasdevelopeddefensestoresideinhostalveolidespitevarioushost-relatedstresscircumstances.Rv1636isauniversalstressproteincontributingtomycobacterialsurvivalindifferenthost-derivedstressconditions.BothATPandcAMPcanbebound[...]Readmore.Mycobacteriumtuberculosishasseentremendoussuccessasithasdevelopeddefensestoresideinhostalveolidespitevarioushost-relatedstresscircumstances.Rv1636isauniversalstressproteincontributingtomycobacterialsurvivalindifferenthost-derivedstressconditions.BothATPandcAMPcanbeboundwiththeRv1636,andtheirbindingactionsareindependentofoneanother.β-Amyrin,atriterpenoidcompound,isabundantinmedicinalplantsandhasmanypharmacologicalpropertiesandbroadtherapeuticpotential.Thecurrentstudyusesbiochemical,biophysical,andcomputationalmethodstodefinethebindingofRv1636withβ-Amyrin.Asubstantialinteractionbetweenβ-AmyrinandRv1636wasdiscoveredbymoleculardockingstudies,whichhelpeddecipherthecriticalresiduesinvolvedinthebindingprocess.VAL60isacrucialresiduefoundinthecomplexesofbothRv1636_β-AmyrinandRv1636-ATP.Additionally,theRv1636_β-Amyrincomplexwasshowntobestablebymoleculardynamicssimulationstudies(MD),withminimalchangesobservedduringthesimulation.Insilicoobservationswerefurthercomplementedbyinvitroassays.Successfulcloning,expression,andpurificationofRv1636wereaccomplishedusingNi-NTAaffinitychromatography.TheresultsoftheATPaseactivityassayindicatedthatRv1636’sATPaseactivitywasinhibitedinthepresenceofvariousβ-Amyrinconcentrations.Additionally,circulardichroismspectroscopy(CD)wasusedtoexaminemodificationstoRv1636secondarystructureuponbindingofβ-Amyrin.Finally,isothermaltitrationcalorimetry(ITC)advocatedspontaneousbindingofβ-AmyrinwithRv1636elucidatingthethermodynamicsoftheRv1636_β-Amyrincomplex.Thus,thestudyestablishesthatβ-AmyrinbindstoRv1636withasignificantaffinityformingastablecomplexandinhibitingitsATPaseactivity.Thepresentstudysuggeststhatβ-AmyrinmightaffectthefunctioningofRv1636,whichmakesthebacteriumvulnerabletodifferentstressconditions.Fullarticle(ThisarticlebelongstotheSpecialIssueProteinDrugTargetsandDrugDesign)attachmentSupplementarymaterial:SupplementaryFile1(ZIP,697KiB)get_appsubjectViewonlineas:AbstractPeOpenAccessArticleElectrochemicalBottom-UpSynthesisofChiralCarbonDotsfromL-ProlineandTheirApplicationasNano-OrganocatalystsinaStereoselectiveAldolReactionbyMartinaBortolami,IngridIzabelaBogles,CeciliaBombelli,FabianaPandolfi,MartaFerociandFabrizioVeticaMolecules2022,27(16),5150;doi.org/10.3390/molecules(registering DOI)-12Aug2022AbstractChiralityisundoubtedlyafundamentalpropertyofnaturesincethedifferentinteractionsofopticallyactivemoleculesinachiralenvironmentareessentialfornumerousapplications.Thus,inthefieldofasymmetricsynthesis,thesearchforefficient,sustainable,cost-effectiveandrecyclablechiralcatalystsis[...]Readmore.Chiralityisundoubtedlyafundamentalpropertyofnaturesincethedifferentinteractionsofopticallyactivemoleculesinachiralenvironmentareessentialfornumerousapplications.Thus,inthefieldofasymmetricsynthesis,thesearchforefficient,sustainable,cost-effectiveandrecyclablechiralcatalystsisstillthemainchallengeinorganicchemistry.Thefieldofcarbondots(CDs)hasexperiencedtremendousdevelopmentinthelast15years,includingtheirapplicationsasachiralcatalysts.Thus,understandingtheimplicationsofchiralityinCDschemistrycouldbeofutmostimportancetoachievingsustainableandbiocompatiblechiralnanocatalysts.Anefficientandcost-effectiveelectrochemicalsyntheticmethodologyforthesynthesisofL-Proline-basedchiralcarbondots(CCDs)andEtOH-derivedL-Proline-basedchiralcarbondots(CCDs)ishereinreported.Theelectrochemicalset-upandreactionconditionshebeenthoroughlyoptimisedandtheireffectsonCCDssize,photoluminescence,aswellascatalyticactivityhebeeninvestigated.TheobtainedCCDshebeensuccessfullyemployedtocatalyzeanasymmetricaldolreaction,showingexcellentresultsintermsofyield,diastereo-andenantioselectivity.Moreover,thesustainablenatureoftheCCDswasdemonstratedbyrecyclingthecatalystsforupto3cycleswithoutanylossofreactivityorstereoselectivity.Fullarticle(ThisarticlebelongstotheSpecialIssueElectrochemistryandOrganometallicCatalysis:ThemedIssueinHonoroftheGreatContributionofProf.Dr.ChristianAmatoreandProf.Dr.AnnyJutand)get_appsubjectViewonlineas:AbstractPeOpenAccessReviewASurveyonMAC-BasedPhysicalLayerSecurityoverWirelessSensorNetworkbyAttiqueUrRehman,MuhammadSajidMahmood,ShoaibZafar,MuhammadAhsanRaza,FahadQaswar,SumayhS.Aljameel,IrfanUllahKhanandNidaAslamElectronics2022,11(16),2529;doi.org/10.3390/electronics(registering DOI)-12Aug2022AbstractPhysicallayersecurityforwirelesssensornetworks(WSNs)isalaboriousandhighlycriticalissueintheworld.Wirelesssensornetworkshegreatimportanceincivilandmilitaryfieldsorapplications.Securityofdata/informationthroughwirelessmediumremainsachallenge.Thedatathat[...]Readmore.Physicallayersecurityforwirelesssensornetworks(WSNs)isalaboriousandhighlycriticalissueintheworld.Wirelesssensornetworkshegreatimportanceincivilandmilitaryfieldsorapplications.Securityofdata/informationthroughwirelessmediumremainsachallenge.Thedatathatwetransmitwirelesslyhasincreasedthespeedoftransmissionrate.Inphysicallayersecurity,thedatatransferbetweensourceanddestinationisnotconfidential,andthustheuserhasprivacyissues,whichiswhyimprovingthesecurityofwirelesssensornetworksisaprimeconcern.Thelossofphysicalsecuritycausesagreatthreattoanetwork.Wehevarioustechniquestoresolvetheseissues,suchasinterference,noise,fadinginthecommunications,etc.Inthispaperwehesurveyedthedifferentparametersofasecuritydesignmodeltohighlightthevulnerabilities.FurtherwehediscussedthevariousattacksondifferentlayersoftheTCP/IPmodelalongwiththeirmitigationtechniques.WealsoelaboratedontheapplicationsofWSNsinhealthcare,militaryinformationintegration,oilandgas.Finally,weheproposedasolutiontoenhancethesecurityofWSNsbyadoptingthealphamethodandhandshakemechanismwithencryptionanddecryption.Fullarticle(ThisarticlebelongstotheSpecialIssueArtificialIntelligenceDrivenSoftware-DefinedNetworking(SDN)TechnologiesforNextGenerationNetworks)attachmentSupplementarymaterial:SupplementaryFile1(ZIP,758KiB)get_appsubjectViewonlineas:AbstractPeOpenAccessArticleIdentificationandCharacterizationofEpithelialCell-DerivedDenseBodiesProduceduponCytomegalovirusInfectionbyEstéfaniGarcía-Ríos,MaríaJosefaRodríguez,MaríaCarmenTerrón,DanielLuqueandPilarPérez-RomeroVaccines2022,10(8),1308;doi.org/10.3390/vaccines(registering DOI)-12Aug2022AbstractDensebodies(DB)arecomplex,noninfectiousparticlesproducedduringCMVinfectioncontainingenvelopeandtegumentproteinsthatmaybeidealcandidatesasvaccines.AlthoughDBwerepreviouslydescribedinfibroblasts,noevidenceofDBformationhasbeenshownafterpropatingCMVinepithelialcells.[...]Readmore.Densebodies(DB)arecomplex,noninfectiousparticlesproducedduringCMVinfectioncontainingenvelopeandtegumentproteinsthatmaybeidealcandidatesasvaccines.AlthoughDBwerepreviouslydescribedinfibroblasts,noevidenceofDBformationhasbeenshownafterpropatingCMVinepithelialcells.Inthepresentstudy,bothfibroblastMRC-5andepithelialARPE-19cellswereusedtostudyDBproductionduringCMVinfection.Wedemonstratetheformationofepithelialcell-derivedDB,mostlylocatedascytoplasmicinclusionsintheperinuclearareaoftheinfectedcell.DBweregradient-purified,andthenatureoftheviralparticleswasconfirmedusingCMV-specificimmunelabeling.Epithelialcell-derivedDBhadhigherdensityandmorehomogeneoussize(200–300nm)comparedtofibroblast-derivedDB(100–600nm).InreementwithpreviousresultscharacterizingDBfromCMV-infectedfibroblasts,thepp65tegumentproteinwaspredominantintheepithelialcell-derivedDB.OurresultsalsosuggestthatepithelialcellshadmoreCMVcapsidsinthecytoplasmandhadsphericalbodiescompatiblewithnucleuscondensation(pyknosis)incellsundergoingapoptosisthatwerenotdetectedinMRC-5infectedcellsatthetestedtimepost-infection.OurresultsdemonstratetheformationofDBinCMV-infectedARPE-19epithelialcellsthatmaybesuitablecandidatetodevelopamultiproteinvaccinewithantigenicpropertiessimilartothatofthevirionswhilenotincludingtheviralgenome.Fullarticle(ThisarticlebelongstotheSpecialIssueVirus-LikeParticle(VLP)Vaccines)MoreArticles...OpenAccessJournalsAcousticsActuatorsAdministrativeSciencesAdolescentsAdvancesinRespiratoryMedicineAerospacericultureriEngineeringrochemicalsronomyAIAlgorithmsAllergiesAlloysAnalyticaAnalyticsAnatomiaAnimalsAntibioticsAntibodiesAntioxidantsAppliedBiosciencesAppliedMechanicsAppliedMicrobiologyAppliedNanoAppliedSciencesAppliedSystemInnovation(ASI)AppliedChemAppliedMathAquacultureJournalArchitectureArthropodaArtsAstronomyAtmosphereAtomsAudiologyResearchAutomationAxiomsBacteriaBatteriesBehioralSciencesBeveresBigDataandCognitiveComputing(BDCC)BioChemBioengineeringBiologicsBiologyBiologyandLifeSciencesForumBiomassBiomechanicsBioMedBiomedicinesBioMedInformaticsBiomimeticsBiomoleculesBiophysicaBiosensorsBioTechBirdsBrainSciencesBuildingsBusinessesCCancersCardiogeneticsCatalystsCellsCeramicsChallengesChemEngineeringChemistryChemistryProceedingsChemosensorsChildrenChipsCivilEngCleanTechnologies(CleanTechnol.)ClimateClinicalandTranslationalNeuroscience(CTN)ClinicsandPracticeClocks&SleepCoastsCoatingsColloidsandInterfacesColorantsCommoditiesCompoundsComputationComputerSciences&MathematicsForumComputersCondensedMatterConservationConstructionMaterialsCorrosionandMaterialsDegradation(CMD)CosmeticsCOVIDCropsCryptographyCrystalsCurrentIssuesinMolecularBiology(CIMB)CurrentOncologyDairyDataDentistryJournalDermatoDermatopathologyDesignsDiabetologyDinosticsDieteticsDigitalDisabilitiesDiseasesDiversityDNADronesDrugsandDrugCandidates(DDC)DynamicsEarthEcologiesEconometricsEconomiesEducationSciencesElectricityElectrochemElectronicMaterialsElectronicsEncyclopediaEndocrinesEnergiesEngEngineeringProceedingsEntropyEnvironmentalSciencesProceedingsEnvironmentsEpidemiologiaEpigenomesEuropeanBurnJournal(EBJ)EuropeanJournalofInvestigationinHealth,PsychologyandEducation(EJIHPE)FermentationFibersFinTechFireFishesFluidsFoodsForecastingForensicSciencesForestsFoundationsFractalandFractional(FractalFract)FuelsFutureFutureInternetFuturePharmacologyFutureTransportationGalaxiesGamesGasesGastroenterologyInsightsGastrointestinalDisordersGelsGenealogyGenesGeographiesGeoHazardsGeomaticsGeosciencesGeotechnicsGeriatricsHealthcareHeartsHematoHematologyReportsHeriteHistoriesHorticulturaeHu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